4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action
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چکیده
منابع مشابه
Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta
Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...
متن کاملsynthesis and effects of novel dihydropyridines as dual calcium channel blocker and angiotensin antagonist on isolated rat aorta
objective(s) four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. the effects of 5a and 5b on angiotensin receptors (at') and l-type calcium channels were investigated on isolated rat aorta. materials and methods aortic rings were pre-contracted with 1 pm angiotensin ii or 80 mm kcl and relaxant effects of losartan, nifedipine, 5a a...
متن کاملQuantitative Structure-Activity Relationship Studies of 4-Imidazolyl- 1,4-dihydropyridines as Calcium Channel Blockers
Objective(s): The structure- activity relationship of a series of 36 molecules, showing L-type calcium channel blocking was studied using a QSAR (quantitative structure–activity relationship) method. Materials and Methods: Structures were optimized by the semi-empirical AM1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. Several types of ...
متن کاملQuantitative Structure-Activity Relationship Studies of 4-Imidazolyl- 1,4-dihydropyridines as Calcium Channel Blockers
OBJECTIVE(S) The structure- activity relationship of a series of 36 molecules, showing L-type calcium channel blocking was studied using a QSAR (quantitative structure-activity relationship) method. MATERIALS AND METHODS Structures were optimized by the semi-empirical AM1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. Several types of d...
متن کاملquantitative structure-activity relationship studies of 4-imidazolyl- 1,4-dihydropyridines as calcium channel blockers
objective(s): the structure- activity relationship of a series of 36 molecules, showing l-type calcium channel blocking was studied using a qsar (quantitative structure–activity relationship) method. materials and methods: structures were optimized by the semi-empirical am1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. several types of d...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2020
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2020/2075815